Moodle is an excellent LMS and Twitter Bootstrap an excellent page design framework so why not put them both together. Here's how.
Create a new theme location on your moodle installation by following these instructions. http://docs.moodle.org/24/en/Themes_FAQ#Why_is_the_new_theme_I_uploaded_not_showing_up_in_Theme_Selector.3F
You may suffer your new theme appearing with the name [[pluginname]]. If so, follow these instructions http://docs.moodle.org/dev/Themes#Getting_Your_Theme_to_Appear_Correctly_in_Theme_Selector
Download the Twitter Bootstrap theme from http://theming.sonsbeekmedia.nl/
Copy the contents of your downloaded theme into this directory.
Finally, you want to be in a situation where you can make your own small tweaks.
Open /theme/bootstrap/config.php
Add 'user_styles' to the end of the '$THEME->sheets' array.
Now create a file called /theme/bootstrap/style/user_styles.css. You can now put your tweaks in there such as:
p
{
font-family:Georgia,Serif;
}