This example makes use of borders and spacing. It's not a bad starting position.
See demo.
<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1">
<title>Design Template 37</title>
<!--[if IE]>
<script src="http://html5shim.googlecode.com/svn/trunk/html5.js"></script>
<![endif]-->
<link rel="stylesheet" href="http://meyerweb.com/eric/tools/css/reset/reset.css" />
<link href='http://fonts.googleapis.com/css?family=Quattrocento&v1' rel='stylesheet' type='text/css'>
<style>
body
{
font:0.96em/1.5em Sans-serif;
width:60em;
margin:auto;
color:#333333;
}
header, nav, section, footer, aside
{
margin:0.5em;
border:0.5em solid #EEEEEE;
}
header, nav, section, footer
{
padding:0.5em;
}
header, section
{
width:36.5em;
}
header, section
{
float:left;
}
nav, aside
{
float:right;
}
section, footer
{
clear:both;
}
nav
{
text-align:center;
width:18em;
height:3em;
padding-top:2em;
background:#94D5F8 url(images/bluefade.png) repeat-x;
}
aside
{
width:19em;
}
img
{
margin:0 0 -0.35em 0;
}
p
{
text-align:justify;
margin-bottom:0.5em;
}
h1
{
color:#0693E2;
font:4em 'Quattrocento', arial, serif;
text-transform:lowercase;
}
h1 .last-letter
{
color:#AAAAAA;
}
nav a
{
margin:0.5em;
text-decoration:none;
color:#FFFFFF;
}
nav a:hover
{
text-decoration:underline;
}
</style>
</head>
<body>
<br />
<header><h1>Header <span class="last-letter">1</span></h1></header>
<nav>
<a href="#">home</a>
<a href="#">services</a>
<a href="#">portfolio</a>
<a href="#">contact</a>
</nav>
<section>
<p>Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Vestibulum tortor quam, feugiat vitae, ultricies eget, tempor sit amet, ante. Donec eu libero sit amet quam egestas semper. Aenean ultricies mi vitae est. Mauris placerat eleifend leo. Quisque sit amet est et sapien ullamcorper pharetra. Vestibulum erat wisi, condimentum sed, commodo vitae, ornare sit amet, wisi. Aenean fermentum, elit eget tincidunt condimentum, eros ipsum rutrum orci, sagittis tempus lacus enim ac dui. Donec non enim in turpis pulvinar facilisis. Ut felis. Praesent dapibus, neque id cursus faucibus, tortor neque egestas augue, eu vulputate magna eros eu erat. Aliquam erat volutpat. Nam dui mi, tincidunt quis, accumsan porttitor, facilisis luctus, metus</p>
<p>Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Vestibulum tortor quam, feugiat vitae, ultricies eget, tempor sit amet, ante. Donec eu libero sit amet quam egestas semper. Aenean ultricies mi vitae est. Mauris placerat eleifend leo.</p>
</section>
<aside>
<img src="http://lorempixum.com/291/300/technics" />
</aside>
<footer><p>Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas.</p></footer>
</body>
</html>